Friday, December 17, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 9:00am | Girls Basketball - Greensburg Salem vs Preston (WV) | |
| 6:00pm | Boys Basketball - Latrobe @ Woodland Hills # | |
| 6:00pm | Girls Basketball - Peters Township @ Penn Hills | |
| 6:00pm | Girls Basketball - Kiski Area @ Franklin Regional | |
| 6:00pm | Girls Basketball - Gateway @ McKeesport # | |
| 6:30pm | Girls Basketball - Butler vs North Hills # | |
| 6:30pm | Girls Basketball - North Allegheny vs Pine-Richland # | |
| 7:00pm | Girls Basketball - Chartiers Valley vs Red Bank Regional (NJ) | |
| 7:30pm | Boys Basketball - Bethel Park vs South Fayette | |
| 7:30pm | Boys Basketball - Mt. Lebanon @ Norwin | |
| 7:30pm | Boys Basketball - Peters Township vs Fox Chapel | |
| 7:30pm | Boys Basketball - Upper St. Clair vs Nazareth Prep | |
| 7:30pm | Boys Basketball - Penn-Trafford @ Connellsville | |
| 7:30pm | Boys Basketball - Ringgold vs West Allegheny | |
| 7:30pm | Boys Basketball - Thomas Jefferson vs Baldwin | |
| 7:30pm | Boys Basketball - West Mifflin vs Brashear | |
| 7:30pm | Boys Basketball - Moon @ Avonworth | |
| 7:30pm | Boys Basketball - Franklin Regional vs Kiski Area # | |
| 7:30pm | Boys Basketball - Penn Hills vs Westinghouse | |
| 7:30pm | Boys Basketball - Hampton vs Plum # | |
| 7:30pm | Boys Basketball - Shaler vs Indiana # | |
| 7:30pm | Boys Basketball - Armstrong vs Mars # | |
| 7:30pm | Girls Basketball - Albert Gallatin vs Allderdice | |
| 7:30pm | Girls Basketball - Woodland Hills vs Homer Center | |
| 8:00pm | Boys Basketball - Butler vs Seneca Valley # | |
| 8:00pm | Boys Basketball - North Allegheny vs Pine-Richland # |
# denotes a conference game