Friday, September 3, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 2:00pm | Girls Soccer - Pine-Richland vs Mercyhurst Prep | |
| 3:00pm | Girls Volleyball - Gateway @ Trinity Christian | |
| 3:00pm | Boys Soccer - Butler vs DuBois Area | |
| 3:30pm | Boys Soccer - Peters Township vs Central Catholic | |
| 3:30pm | Boys Soccer - Allderdice vs Brashear | |
| 4:00pm | Boys Soccer - Seneca Valley vs Baldwin | |
| 4:00pm | Boys Soccer - Hempfield vs Greensburg Salem | |
| 4:00pm | Boys Soccer - Norwin vs Chartiers Valley | |
| 4:00pm | Boys Soccer - Mt. Lebanon @ Exeter Township | |
| 4:15pm | Girls Soccer - Fox Chapel vs Hampton | |
| 5:00pm | Girls Soccer - Peters Township vs McDowell | |
| 5:00pm | Boys Soccer - Upper St. Clair @ Plum | |
| 7:00pm | Boys Soccer - Pine-Richland vs North Catholic | |
| 7:00pm | Girls Volleyball - Gateway vs Penn Hills | |
| 7:30pm | Girls Volleyball - Latrobe vs Laurel | |
| 8:00pm | Football - Baldwin vs Bethel Park | |
| 8:00pm | Football - Canon-McMillan vs Peters Township | |
| 8:00pm | Football - Central Catholic vs Penn Hills | |
| 8:00pm | Football - Mt. Lebanon vs Upper St. Clair | |
| 8:00pm | Football - North Allegheny @ Pickerington Central (OH) | |
| 8:00pm | Football - Norwin vs Latrobe | |
| 8:00pm | Football - Moon vs Montour | |
| 8:00pm | Football - South Fayette vs West Mifflin | |
| 8:00pm | Football - West Allegheny @ Trinity | |
| 8:00pm | Football - Connellsville @ Greensburg Salem | |
| 8:00pm | Football - Franklin Regional @ Kiski Area | |
| 8:00pm | Football - Gateway vs Thomas Jefferson | |
| 8:00pm | Football - Fox Chapel vs Hampton | |
| 8:00pm | Football - North Hills vs Plum | |
| 8:00pm | Football - Shaler vs Mars | |
| 8:00pm | Girls Soccer - Mt. Lebanon @ South Park | |
| 8:30pm | Football - Hempfield @ Penn-Trafford | |
| 9:30pm | Football - Seneca Valley vs Pine-Richland |
# denotes a conference game