Tuesday, April 6, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:45pm | Baseball - Mars vs Armstrong # | |
| 4:45pm | Softball - Fox Chapel vs Peters Township | |
| 5:00pm | Baseball - Seneca Valley vs North Allegheny # | |
| 5:00pm | Baseball - Norwin vs Baldwin # | |
| 5:00pm | Baseball - Pine-Richland @ Central Catholic # | |
| 5:00pm | Baseball - Franklin Regional @ Penn-Trafford # | |
| 5:00pm | Baseball - Gateway @ Kiski Area # | |
| 5:00pm | Baseball - Penn Hills vs Hampton # | |
| 5:00pm | Baseball - South Fayette vs Moon # | |
| 5:00pm | Baseball - Thomas Jefferson vs Albert Gallatin # | |
| 5:00pm | Baseball - Connellsville vs Peters Township # | |
| 5:00pm | Baseball - Bethel Park vs Trinity # | |
| 5:00pm | Softball - Hempfield vs Franklin Regional | |
| 5:00pm | Softball - Plum vs Gateway | |
| 5:00pm | Softball - Connellsville vs Kiski Area | |
| 5:00pm | Softball - Pine-Richland @ Deer Lakes | |
| 5:00pm | Softball - West Allegheny vs Shaler | |
| 5:00pm | Softball - Armstrong @ Woodland Hills # | |
| 5:15pm | Baseball - Upper St. Clair @ Hempfield # | |
| 5:15pm | Baseball - Shaler vs Chartiers Valley # | |
| 6:00pm | Baseball - Canon-McMillan vs Mt. Lebanon # | |
| 6:00pm | Baseball - West Allegheny @ North Hills # | |
| 8:00pm | Baseball - Butler @ Allderdice # | |
| 8:00pm | Baseball - Latrobe vs McKeesport # | |
| 8:00pm | Softball - Bethel Park @ North Allegheny |
# denotes a conference game