Wednesday, May 4, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 4:00pm | Softball - Norwin @ Greensburg Salem | |
| 4:00pm | Softball - Hampton vs Highlands | |
| 4:00pm | Softball - Thomas Jefferson vs South Park | |
| 4:15pm | Baseball - Moon vs West Allegheny # | |
| 4:15pm | Softball - Western Beaver @ Beaver Falls | |
| 4:30pm | Baseball - Allderdice vs Central Catholic # | |
| 4:30pm | Softball - Moon vs West Allegheny # | |
| 5:00pm | Baseball - Canon-McMillan vs Baldwin # | |
| 5:00pm | Softball - Peters Township @ North Hills | |
| 5:00pm | Softball - Pine-Richland vs Mars | |
| 5:00pm | Softball - Armstrong @ Indiana # | |
| 5:00pm | Baseball - Plum @ Avonworth | |
| 5:00pm | Softball - Albert Gallatin vs Mapletown | |
| 6:00pm | Softball - Woodland Hills @ Gateway | |
| 7:30pm | Softball - Baldwin vs Peters Township # | |
| 8:00pm | Baseball - Butler @ Seneca Valley # | |
| 8:00pm | Baseball - North Allegheny vs Pine-Richland # | |
| 8:00pm | Softball - Trinity vs Upper St. Clair # |
# denotes a conference game