Wednesday, April 14, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 3:30pm | Baseball - Kiski Area vs McKeesport # | |
| 4:45pm | Softball - Fox Chapel @ Mars # | |
| 4:45pm | Softball - South Fayette vs Western Beaver # | |
| 5:00pm | Baseball - Butler @ Central Catholic # | |
| 5:00pm | Baseball - Seneca Valley vs Pine-Richland # | |
| 5:00pm | Baseball - Hempfield vs Baldwin # | |
| 5:00pm | Baseball - North Hills vs Chartiers Valley # | |
| 5:00pm | Baseball - Shaler vs Moon # | |
| 5:00pm | Baseball - South Fayette vs West Allegheny # | |
| 5:00pm | Baseball - Bethel Park vs Albert Gallatin # | |
| 5:00pm | Softball - Bethel Park vs Peters Township # | |
| 5:00pm | Softball - Pine-Richland vs Butler # | |
| 5:00pm | Softball - North Allegheny @ Hempfield # | |
| 5:00pm | Softball - Plum vs Armstrong # | |
| 5:00pm | Softball - Franklin Regional vs Indiana # | |
| 5:00pm | Softball - Kiski Area @ Penn Hills # | |
| 5:00pm | Softball - Penn-Trafford vs Connellsville # | |
| 5:00pm | Softball - Latrobe vs Thomas Jefferson # | |
| 5:00pm | Softball - North Hills vs Hampton # | |
| 5:00pm | Softball - Shaler vs Oakland Catholic # | |
| 5:00pm | Softball - West Allegheny @ Trinity # | |
| 5:15pm | Softball - Mt. Lebanon vs Canon-McMillan # | |
| 8:00pm | Softball - Chartiers Valley @ Upper St. Clair # |
# denotes a conference game