Friday, October 29, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 8:00pm | Football - Baldwin vs Mt. Lebanon # | |
| 8:00pm | Football - Canon-McMillan vs Central Catholic # | |
| 8:00pm | Football - Hempfield vs Norwin # | |
| 8:00pm | Football - North Allegheny @ Seneca Valley # | |
| 8:00pm | Football - Bethel Park vs Upper St. Clair # | |
| 8:00pm | Football - Moon @ West Allegheny # | |
| 8:00pm | Football - Peters Township @ South Fayette # | |
| 8:00pm | Football - Connellsville vs Woodland Hills # | |
| 8:00pm | Football - Franklin Regional vs Gateway # | |
| 8:00pm | Football - Latrobe vs Penn-Trafford # | |
| 8:00pm | Football - Fox Chapel vs Pine-Richland # | |
| 8:00pm | Football - Kiski Area vs Penn Hills # | |
| 8:00pm | Football - North Hills @ Shaler # |
# denotes a conference game