Friday, October 21, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 8:00pm | Football - Canon-McMillan vs Peters Township | |
| 8:00pm | Football - Central Catholic @ Seneca Valley # | |
| 8:00pm | Football - Franklin Regional @ North Hills | |
| 8:00pm | Football - Gateway vs Norwin # | |
| 8:00pm | Football - Fox Chapel @ Kiski Area | |
| 8:00pm | Football - Pine-Richland vs Woodland Hills # | |
| 8:00pm | Football - Mt. Lebanon vs Baldwin | |
| 8:00pm | Football - Bethel Park @ South Fayette # | |
| 8:00pm | Football - Moon vs Upper St. Clair # | |
| 8:00pm | Football - Hempfield @ Plum # | |
| 8:00pm | Football - Penn Hills vs Shaler # | |
| 8:30pm | Football - North Allegheny vs Penn-Trafford |
# denotes a conference game