Friday, September 16, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 8:00pm | Football - Canon-McMillan vs Bethel Park | |
| 8:00pm | Football - Central Catholic vs Mt. Lebanon # | |
| 8:00pm | Football - Seneca Valley @ Pine-Richland | |
| 8:00pm | Football - Peters Township vs South Fayette # | |
| 8:00pm | Football - Franklin Regional vs Gateway # | |
| 8:00pm | Football - Penn-Trafford @ Belle Vernon | |
| 8:00pm | Football - Fox Chapel vs Upper St. Clair | |
| 8:00pm | Football - Moon vs Penn Hills | |
| 8:00pm | Football - Hempfield @ Shaler | |
| 8:00pm | Football - Norwin @ Plum # | |
| 8:00pm | Football - North Hills @ Woodland Hills # | |
| 9:30pm | Football - North Allegheny vs Baldwin |
# denotes a conference game