Friday, September 9, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 8:00pm | Football - Canon-McMillan @ Seneca Valley # | |
| 8:00pm | Football - Central Catholic @ Bethel Park | |
| 8:00pm | Football - Peters Township vs Trinity | |
| 8:00pm | Football - Franklin Regional @ Connellsville | |
| 8:00pm | Football - Gateway @ North Hills | |
| 8:00pm | Football - Fox Chapel @ Norwin | |
| 8:00pm | Football - Mt. Lebanon @ Moon | |
| 8:00pm | Football - Baldwin @ Upper St. Clair # | |
| 8:00pm | Football - South Fayette vs Montour | |
| 8:00pm | Football - Hempfield @ Latrobe | |
| 8:00pm | Football - Plum vs Shaler | |
| 8:30pm | Football - North Allegheny vs McDowell | |
| 8:30pm | Football - Penn-Trafford vs Woodland Hills | |
| 9:00pm | Football - Pine-Richland @ Penn Hills # |
# denotes a conference game