Friday, September 2, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 8:00pm | Football - Canon-McMillan vs North Allegheny # | |
| 8:00pm | Football - Central Catholic vs Lincoln | |
| 8:00pm | Football - Seneca Valley vs Peters Township | |
| 8:00pm | Football - Franklin Regional vs Latrobe | |
| 8:00pm | Football - Gateway vs Woodland Hills | |
| 8:00pm | Football - Fox Chapel vs Plum | |
| 8:00pm | Football - Pine-Richland @ Kiski Area | |
| 8:00pm | Football - Baldwin vs Thomas Jefferson | |
| 8:00pm | Football - Moon @ Montour | |
| 8:00pm | Football - South Fayette @ West Allegheny | |
| 8:00pm | Football - Upper St. Clair @ North Hills | |
| 8:00pm | Football - Hempfield vs Connellsville | |
| 8:00pm | Football - Norwin @ Penn Hills | |
| 8:00pm | Football - Shaler vs Hampton | |
| 8:30pm | Football - Penn-Trafford vs McKeesport | |
| 9:00pm | Football - Mt. Lebanon vs Bethel Park |
# denotes a conference game