Wednesday, December 22, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 6:00pm | Girls Basketball - Gateway @ Freeport | |
| 7:30pm | Boys Basketball - Peters Township @ Seton LaSalle | |
| 7:30pm | Boys Basketball - Upper St. Clair vs Elizabeth Forward | |
| 7:30pm | Boys Basketball - Laurel Highlands vs Trinity | |
| 7:30pm | Boys Basketball - West Mifflin @ Armstrong | |
| 7:30pm | Boys Basketball - Highlands @ Knoch | |
| 7:30pm | Girls Basketball - North Hills vs Canon-McMillan | |
| 7:30pm | Girls Basketball - Penn-Trafford @ Hempfield | |
| 7:30pm | Girls Basketball - Seneca Valley @ Slippery Rock | |
| 7:30pm | Girls Basketball - Mt. Lebanon vs Oakland Catholic | |
| 7:30pm | Girls Basketball - Peters Township @ Moon | |
| 7:30pm | Girls Basketball - Mars vs Knoch |
# denotes a conference game