Friday, October 8, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 8:00pm | Football - Baldwin @ Hempfield # | |
| 8:00pm | Football - Bethel Park @ South Fayette # | |
| 8:00pm | Football - Upper St. Clair @ West Allegheny # | |
| 8:00pm | Football - Connellsville @ Latrobe # | |
| 8:00pm | Football - Franklin Regional vs Woodland Hills # | |
| 8:00pm | Football - Fox Chapel @ Kiski Area # | |
| 8:00pm | Football - North Hills @ Penn Hills # | |
| 8:00pm | Football - Pine-Richland @ Shaler # | |
| 8:30pm | Football - Canon-McMillan @ Seneca Valley # | |
| 8:30pm | Football - Gateway @ Penn-Trafford # | |
| 10:30pm | Football - North Allegheny vs Norwin # |
# denotes a conference game