Tuesday, May 25, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 3:00pm | Baseball - North Allegheny vs Butler | |
| 4:00pm | Softball - Fox Chapel vs Armstrong | |
| 5:30pm | Baseball - Bethel Park vs West Allegheny | |
| 6:00pm | Baseball - Franklin Regional vs Peters Township | |
| 7:00pm | Softball - Chartiers Valley vs North Hills | |
| 7:30pm | Baseball - Hempfield vs Norwin |
# denotes a conference game