Tuesday, April 20, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:45pm | Baseball - Trinity @ Mars | |
| 4:45pm | Softball - Hampton @ Mars # | |
| 4:45pm | Softball - Fox Chapel vs Oakland Catholic # | |
| 5:00pm | Baseball - Seneca Valley vs Allderdice # | |
| 5:00pm | Baseball - Norwin @ Canon-McMillan # | |
| 5:00pm | Baseball - Upper St. Clair @ Baldwin # | |
| 5:00pm | Baseball - Franklin Regional vs McKeesport # | |
| 5:00pm | Baseball - Penn-Trafford @ Kiski Area # | |
| 5:00pm | Baseball - Fox Chapel vs Hampton # | |
| 5:00pm | Baseball - Armstrong vs Penn Hills # | |
| 5:00pm | Baseball - Shaler @ South Fayette # | |
| 5:00pm | Softball - Bethel Park vs Baldwin # | |
| 5:00pm | Softball - Pine-Richland vs North Allegheny # | |
| 5:00pm | Softball - Seneca Valley @ Butler # | |
| 5:00pm | Softball - Armstrong @ Indiana # | |
| 5:00pm | Softball - Kiski Area @ Franklin Regional # | |
| 5:00pm | Softball - Plum @ Penn Hills # | |
| 5:00pm | Softball - Thomas Jefferson vs Gateway # | |
| 5:00pm | Softball - Penn-Trafford @ Latrobe # | |
| 5:00pm | Softball - North Hills vs Shaler # | |
| 5:00pm | Softball - Chartiers Valley @ South Fayette # | |
| 5:00pm | Softball - Trinity vs Upper St. Clair # | |
| 5:00pm | Softball - West Allegheny @ Moon # | |
| 5:00pm | Softball - Western Beaver @ Aliquippa | |
| 5:15pm | Baseball - Moon vs North Hills # | |
| 5:15pm | Baseball - West Allegheny @ Chartiers Valley # | |
| 8:00pm | Baseball - North Allegheny vs Central Catholic # | |
| 8:00pm | Baseball - Gateway vs Latrobe # | |
| 8:00pm | Baseball - Bethel Park @ Peters Township # | |
| 8:30pm | Baseball - Butler vs Pine-Richland # |
# denotes a conference game