Thursday, April 22, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:30pm | Baseball - Allderdice vs Brashear | |
| 4:30pm | Softball - Chartiers Valley @ Moon # | |
| 4:45pm | Baseball - North Allegheny @ Hampton | |
| 4:45pm | Softball - South Fayette vs Upper St. Clair # | |
| 4:45pm | Softball - Fox Chapel vs Butler | |
| 4:45pm | Softball - Hampton vs Knoch | |
| 4:45pm | Softball - Pine-Richland @ Mars | |
| 5:00pm | Baseball - Fox Chapel vs Woodland Hills # | |
| 5:00pm | Baseball - Canon-McMillan @ Laurel Highlands | |
| 5:00pm | Baseball - Seneca Valley vs Chartiers Valley | |
| 5:00pm | Baseball - Kiski Area @ Burrell | |
| 5:00pm | Baseball - Pine-Richland vs Mars | |
| 5:00pm | Baseball - Shaler @ Hopewell | |
| 5:00pm | Baseball - Bethel Park vs Upper St. Clair | |
| 5:00pm | Softball - Norwin vs Seneca Valley # | |
| 5:00pm | Softball - Armstrong @ Franklin Regional # | |
| 5:00pm | Softball - Kiski Area @ Woodland Hills # | |
| 5:00pm | Softball - Plum @ Indiana # | |
| 5:00pm | Softball - West Allegheny @ Western Beaver # | |
| 5:00pm | Softball - Connellsville vs Belle Vernon | |
| 5:00pm | Softball - Hempfield @ Baldwin | |
| 5:15pm | Baseball - Mt. Lebanon vs Hempfield # | |
| 5:15pm | Baseball - North Hills @ Quaker Valley | |
| 5:15pm | Softball - North Allegheny @ Canon-McMillan | |
| 8:00pm | Baseball - Penn-Trafford @ Gateway # | |
| 8:00pm | Baseball - Thomas Jefferson @ Belle Vernon |
# denotes a conference game