Friday, October 21, 2016
| Time | Event | Venue/Details |
|---|---|---|
| 7:00pm | Football - North Allegheny @ Hempfield | |
| 7:00pm | Football - Baldwin vs Moon # | |
| 7:00pm | Football - Chartiers Valley @ Fox Chapel # | |
| 7:00pm | Football - Hampton vs Upper St. Clair # | |
| 7:00pm | Football - North Hills @ Franklin Regional | |
| 7:00pm | Football - West Allegheny @ Woodland Hills # | |
| 7:00pm | Football - Armstrong @ Connellsville # | |
| 7:00pm | Football - Gateway @ McKeesport # | |
| 7:00pm | Football - Kiski Area vs Penn-Trafford # | |
| 7:00pm | Football - Latrobe @ Plum # | |
| 7:30pm | Football - Butler vs Pine-Richland # | |
| 7:30pm | Football - Central Catholic vs Norwin | |
| 7:30pm | Football - Penn Hills @ Mt. Lebanon | |
| 7:30pm | Football - Seneca Valley vs Shaler # | |
| 7:30pm | Football - Altoona @ Bethel Park # | |
| 7:30pm | Football - Canon-McMillan @ Peters Township # |
# denotes a conference game