Tuesday, December 21, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 5:30pm | Girls Basketball - Kiski Area vs Hampton # | |
| 6:00pm | Girls Basketball - Plum vs Armstrong # | |
| 6:00pm | Girls Basketball - Latrobe @ Penn Hills # | |
| 7:00pm | Boys Basketball - Kiski Area vs McKeesport # | |
| 7:00pm | Girls Basketball - Fox Chapel vs Burrell | |
| 7:00pm | Girls Basketball - McKeesport @ Brashear | |
| 7:30pm | Boys Basketball - Butler @ Pine-Richland # | |
| 7:30pm | Boys Basketball - North Allegheny vs Mt. Lebanon | |
| 7:30pm | Boys Basketball - North Hills @ Seneca Valley # | |
| 7:30pm | Boys Basketball - Bethel Park vs Obama Academy | |
| 7:30pm | Boys Basketball - Fox Chapel @ Baldwin | |
| 7:30pm | Boys Basketball - Connellsville vs Indiana | |
| 7:30pm | Boys Basketball - Ringgold @ South Fayette | |
| 7:30pm | Boys Basketball - Thomas Jefferson @ Moon | |
| 7:30pm | Boys Basketball - West Mifflin vs Allderdice | |
| 7:30pm | Boys Basketball - West Allegheny @ Seton LaSalle | |
| 7:30pm | Boys Basketball - Franklin Regional @ Woodland Hills # | |
| 7:30pm | Boys Basketball - Latrobe @ Penn Hills # | |
| 7:30pm | Boys Basketball - Hampton @ Highlands # | |
| 7:30pm | Boys Basketball - Plum vs Armstrong # | |
| 7:30pm | Boys Basketball - Shaler @ Mars # | |
| 7:30pm | Girls Basketball - Upper St. Clair vs Baldwin # | |
| 7:30pm | Girls Basketball - Albert Gallatin vs Brownsville | |
| 7:30pm | Girls Basketball - Trinity @ Uniontown # |
# denotes a conference game