Friday, November 12, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 7:00pm | Football - Gateway vs Penn Hills | |
| 7:00pm | Football - Penn-Trafford vs Fox Chapel | |
| 7:00pm | Football - Pine-Richland vs Peters Township | |
| 7:00pm | Football - Mt. Lebanon vs North Allegheny | |
| 7:00pm | Football - Central Catholic vs Seneca Valley | |
| 7:30pm | Football - Moon vs Woodland Hills |
# denotes a conference game