Friday, October 15, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 5:15pm | Girls Soccer - Shaler vs Baldwin | |
| 7:30pm | Girls Volleyball - Peters Township @ Ringgold | |
| 8:00pm | Football - Canon-McMillan vs North Allegheny # | |
| 8:00pm | Football - Central Catholic @ Hempfield # | |
| 8:00pm | Football - Mt. Lebanon @ Norwin # | |
| 8:00pm | Football - Bethel Park vs Peters Township # | |
| 8:00pm | Football - Moon vs Upper St. Clair # | |
| 8:00pm | Football - South Fayette @ West Allegheny # | |
| 8:00pm | Football - Connellsville vs Penn-Trafford # | |
| 8:00pm | Football - Franklin Regional @ Latrobe # | |
| 8:00pm | Football - Gateway vs Woodland Hills # | |
| 8:00pm | Football - Fox Chapel vs Penn Hills # | |
| 8:00pm | Football - Kiski Area @ Shaler # | |
| 8:00pm | Football - North Hills vs Pine-Richland # | |
| 9:00pm | Football - Baldwin vs Seneca Valley # |
# denotes a conference game