Friday, October 1, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 5:30pm | Boys Soccer - Shaler vs Hempfield | |
| 7:00pm | Football - Mt. Lebanon vs North Allegheny # | |
| 7:00pm | Boys Soccer - Allderdice @ Hempfield # | |
| 8:00pm | Football - Baldwin vs Norwin # | |
| 8:00pm | Football - Canon-McMillan vs Hempfield # | |
| 8:00pm | Football - Central Catholic vs Seneca Valley # | |
| 8:00pm | Football - Bethel Park vs West Allegheny # | |
| 8:00pm | Football - Moon vs South Fayette # | |
| 8:00pm | Football - Peters Township @ Upper St. Clair # | |
| 8:00pm | Football - Connellsville vs Franklin Regional # | |
| 8:00pm | Football - Gateway vs Latrobe # | |
| 8:00pm | Football - Penn-Trafford @ Woodland Hills # | |
| 8:00pm | Football - Fox Chapel vs Shaler # | |
| 8:00pm | Football - Kiski Area @ North Hills # | |
| 8:00pm | Football - Penn Hills @ Pine-Richland # |
# denotes a conference game