Friday, September 17, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 3:30pm | Girls Soccer - Allderdice vs Latrobe # | |
| 3:30pm | Girls Soccer - Fox Chapel @ Norwin # | |
| 8:00pm | Football - Central Catholic vs Norwin # | |
| 8:00pm | Football - Bethel Park vs Gateway | |
| 8:00pm | Football - Moon vs North Hills | |
| 8:00pm | Football - Peters Township @ Penn-Trafford | |
| 8:00pm | Football - South Fayette vs Chartiers Valley | |
| 8:00pm | Football - Upper St. Clair @ Pine-Richland | |
| 8:00pm | Football - West Allegheny vs Shaler | |
| 8:00pm | Football - Connellsville @ Kiski Area | |
| 8:00pm | Football - Franklin Regional vs Fox Chapel | |
| 8:00pm | Football - Latrobe vs Mount Pleasant | |
| 8:00pm | Football - Woodland Hills @ Penn Hills | |
| 8:30pm | Football - Canon-McMillan @ Mt. Lebanon # | |
| 8:30pm | Football - Hempfield @ Seneca Valley # | |
| 9:00pm | Football - Baldwin vs North Allegheny # |
# denotes a conference game