Tuesday, May 18, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:00pm | Softball - Armstrong vs South Fayette | |
| 4:00pm | Softball - Plum vs Fox Chapel | |
| 4:00pm | Softball - West Allegheny vs Franklin Regional | |
| 4:00pm | Baseball - Franklin Regional vs Thomas Jefferson | |
| 6:00pm | Softball - Penn-Trafford vs Hampton | |
| 6:00pm | Softball - Shaler vs Connellsville | |
| 6:00pm | Softball - Latrobe vs Indiana | |
| 7:00pm | Softball - North Hills vs Trinity | |
| 8:00pm | Softball - Chartiers Valley vs Thomas Jefferson |
# denotes a conference game