Wednesday, May 5, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:00pm | Baseball - North Allegheny @ Pine-Richland # | |
| 4:45pm | Softball - Fox Chapel @ Oakland Catholic # | |
| 4:45pm | Softball - Hampton vs Mars # | |
| 5:00pm | Baseball - Norwin vs Hempfield # | |
| 5:00pm | Baseball - Mt. Lebanon @ Upper St. Clair # | |
| 5:00pm | Baseball - Mars @ Penn Hills # | |
| 5:00pm | Baseball - Trinity vs Albert Gallatin # | |
| 5:00pm | Softball - Seneca Valley vs Butler # | |
| 5:00pm | Softball - Norwin vs Hempfield # | |
| 5:00pm | Softball - Franklin Regional vs Woodland Hills # | |
| 5:00pm | Softball - Latrobe vs Penn-Trafford # | |
| 5:30pm | Softball - Bethel Park @ West Mifflin | |
| 6:30pm | Softball - Franklin Regional vs Woodland Hills # | |
| 8:00pm | Baseball - Woodland Hills vs Carrick | |
| 8:00pm | Softball - Trinity vs Chartiers Valley # |
# denotes a conference game