Thursday, April 15, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:30pm | Baseball - Allderdice @ Westinghouse | |
| 4:30pm | Softball - South Fayette @ Moon # | |
| 4:45pm | Baseball - Seneca Valley @ Hampton | |
| 5:00pm | Baseball - Connellsville vs Laurel Highlands | |
| 5:00pm | Baseball - Penn-Trafford vs Seton-LaSalle | |
| 5:00pm | Baseball - South Fayette @ Upper St. Clair | |
| 5:00pm | Baseball - West Allegheny @ Beaver | |
| 5:00pm | Softball - Chartiers Valley vs Trinity # | |
| 5:00pm | Softball - Upper St. Clair vs Western Beaver # | |
| 5:00pm | Softball - Seneca Valley vs Plum | |
| 6:00pm | Softball - Indiana vs Penn Hills # | |
| 6:30pm | Baseball - North Hills @ Knoch | |
| 8:00pm | Baseball - North Allegheny vs Mt. Lebanon |
# denotes a conference game