Wednesday, April 7, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:30pm | Baseball - Butler vs Allderdice # | |
| 4:30pm | Softball - Moon vs Upper St. Clair # | |
| 4:45pm | Baseball - Mars @ Armstrong # | |
| 4:45pm | Softball - South Fayette vs Butler | |
| 4:45pm | Softball - Mars vs Freeport | |
| 4:45pm | Softball - Fox Chapel vs North Allegheny | |
| 5:00pm | Baseball - Central Catholic @ Pine-Richland # | |
| 5:00pm | Baseball - Baldwin vs Norwin # | |
| 5:00pm | Baseball - Gateway vs Kiski Area # | |
| 5:00pm | Baseball - Latrobe @ McKeesport # | |
| 5:00pm | Baseball - Franklin Regional vs Penn-Trafford # | |
| 5:00pm | Baseball - Hampton vs Penn Hills # | |
| 5:00pm | Softball - Franklin Regional vs Plum # | |
| 5:00pm | Softball - Bethel Park @ Chartiers Valley | |
| 5:00pm | Softball - Seneca Valley vs Canon-McMillan | |
| 5:00pm | Softball - Kiski Area vs Knoch | |
| 5:00pm | Softball - Mt. Lebanon @ West Allegheny | |
| 5:00pm | Softball - Hempfield vs Penn-Trafford | |
| 5:00pm | Softball - North Hills vs Pine-Richland | |
| 5:15pm | Baseball - Mt. Lebanon vs Canon-McMillan # | |
| 5:15pm | Baseball - Shaler @ Chartiers Valley # | |
| 5:15pm | Baseball - South Fayette @ Moon # | |
| 5:15pm | Baseball - Albert Gallatin vs Thomas Jefferson # | |
| 5:30pm | Baseball - West Allegheny vs North Hills # | |
| 5:30pm | Softball - Hampton @ Highlands | |
| 7:00pm | Baseball - North Allegheny vs Seneca Valley # | |
| 8:00pm | Baseball - Hempfield @ Upper St. Clair # | |
| 8:00pm | Baseball - Bethel Park @ Trinity # | |
| 8:00pm | Baseball - Connellsville @ Peters Township # |
# denotes a conference game