Thursday, February 25, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 5:00pm | Girls Basketball - Pine-Richland @ Shaler # | |
| 6:00pm | Boys Basketball - Kiski Area vs Woodland Hills # | |
| 6:00pm | Girls Basketball - Indiana vs Plum # | |
| 6:30pm | Boys Basketball - Connellsville vs Ringgold # | |
| 7:00pm | Boys Basketball - Hampton vs Armstrong # | |
| 7:00pm | Boys Basketball - Penn Hills vs Central Catholic | |
| 7:00pm | Boys Basketball - North Allegheny vs Latrobe | |
| 7:00pm | Boys Basketball - Pine-Richland vs Norwin | |
| 7:30pm | Boys Basketball - Bethel Park @ St. Joseph | |
| 7:30pm | Boys Basketball - Plum vs Burrell | |
| 7:30pm | Boys Basketball - Moon vs Carlynton | |
| 7:30pm | Boys Basketball - Peters Township vs Seton-LaSalle | |
| 7:30pm | Girls Basketball - Trinity vs Ringgold # | |
| 7:30pm | Girls Basketball - Latrobe vs Woodland Hills # | |
| 7:30pm | Girls Basketball - Chartiers Valley @ Upper St. Clair | |
| 7:30pm | Girls Basketball - Hampton @ Knoch | |
| 7:30pm | Girls Basketball - Mars @ Burrell | |
| 7:30pm | Girls Basketball - South Fayette vs Thomas Jefferson |
# denotes a conference game