Monday, February 22, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:00pm | Girls Basketball - Butler @ Penn-Trafford # | |
| 6:00pm | Boys Basketball - Highlands @ Hampton # | |
| 6:00pm | Girls Basketball - Armstrong vs Kiski Area # | |
| 6:00pm | Girls Basketball - Gateway @ Greensburg Salem # | |
| 7:00pm | Boys Basketball - Penn-Trafford vs Central Catholic # | |
| 7:00pm | Girls Basketball - West Allegheny vs Carlynton | |
| 7:30pm | Boys Basketball - Butler @ North Allegheny # | |
| 7:30pm | Boys Basketball - Laurel Highlands vs Connellsville # | |
| 7:30pm | Boys Basketball - West Allegheny vs Moon # | |
| 7:30pm | Boys Basketball - Franklin Regional vs Woodland Hills # | |
| 7:30pm | Boys Basketball - Albert Gallatin @ Hempfield | |
| 7:30pm | Boys Basketball - Armstrong @ Kiski Area | |
| 7:30pm | Boys Basketball - Bethel Park @ South Fayette | |
| 7:30pm | Boys Basketball - McKeesport @ South Allegheny | |
| 7:30pm | Boys Basketball - Seneca Valley vs Norwin | |
| 7:30pm | Boys Basketball - New Castle vs Sharon | |
| 7:30pm | Girls Basketball - North Allegheny @ Norwin # | |
| 7:30pm | Girls Basketball - Seneca Valley @ Pine-Richland # | |
| 7:30pm | Girls Basketball - Bethel Park vs Hempfield # | |
| 7:30pm | Girls Basketball - Mt. Lebanon @ Canon-McMillan # | |
| 7:30pm | Girls Basketball - South Fayette vs Moon # | |
| 7:30pm | Girls Basketball - Albert Gallatin vs Connellsville # | |
| 7:30pm | Girls Basketball - Trinity @ Thomas Jefferson # | |
| 7:30pm | Girls Basketball - Woodland Hills vs Franklin Regional # | |
| 7:30pm | Girls Basketball - Chartiers Valley @ Peters Township | |
| 7:30pm | Girls Basketball - Penn Hills vs Oakland Catholic | |
| 8:00pm | Boys Basketball - Fox Chapel @ Greensburg Salem # |
# denotes a conference game